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Our CBD N’ PSILO topical is an Anti-Anxiety & Pain Relief Cream. CBD N’ PSILO combines psilocybin (Psilocybe cubensis) mushroom extract with full spectrum CBD oil and a proprietary combination of other botanical pain relievers, including lavender, chamomile and menthol. CBD N’ PSILO also includes a therapeutic essential oil blend and cacao, shea butter and oat milk as skin nourishing agents.

  • Immediate pain relief
  • Anti-anxiety & stress support
  • Great for joint pain
  • Sore muscle recovery
  • Great for lower back and neck pain
  • Relief of general aches and pains
  • Arthritis relief
  • Relieves tension headaches
The Science Behind the Ingredients in LIMITLESS MUSHROOMS CBD N’ PSILO Cream

Psilocybin Mushroom Extract
Research shows that psilocybin can bind to serotonin receptors in the brain and have positive effects on reducing anxiety. Psilocybin is rapidly dephosphorylated into the active compound psilocin, which activates serotonin 2A (5-HT2A) receptors in the central nervous system (CNS), mimicking the effects of serotonin. Psilocybin also modulates other neurotransmitters in the brain, which deliver anti-anxiety effects. These same effects can also help reduce the feelings of pain. Psilocybin has a molecular weight well under 500 daltons and therefore can be absorbed topically through the skin. After the psilocybin is absorbed it is dephosphorylated and made into psilocin so it can exert its biological effects.

Full Spectrum CBD Oil
CBD targets serotonin receptors, vanilloid receptor TRPV1 (which modulates heat and pain) and GPR55 receptor (G protein-coupled receptor 55), which is a novel cannabinoid receptor that modulates inflammation and pain. Through these various mechanisms of action, CBD acts as a powerful anti-inflammatory and pain killer.

Lavender has anti-inflammatory and calming properties and can help relieve pain. Lavender can help resolve migraine and headache issues and it’s especially beneficial if your headache onset is around nighttime, as it can aid in your sleep as well. Lavender can even help support skin health.

German Chamomile
Research studies show that German chamomile has potent anti-inflammatory properties and can help relieve pain, especially for conditions such as back pain, arthritis and headaches. Both Roman and German chamomile contain the most researched active ingredient, chamazulene, but it is higher in German chamomile.

Menthol is an organic compound made from peppermint oil. Menthol is an effective treatment for muscle aches and joint pain (such as arthritis, backache, sprains etc). Menthol works by causing your skin, muscles and joints to feel cool and then warm sensations. These sensations help alleviate you from feeling the aches and pains deeper in your muscles and joints.


50 mL


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